Genes: The Atomic Rules
A gene is the smallest unit of decision-making in your company. It’s a single, explicit rule that eliminates ambiguity and shapes behavior.Human vs AI: Ownership of Work
Humans own:- Purpose, ethics, risk, and irreversible commitments.
- Novel or ambiguous decisions without precedent.
- Exceptions to policy and cross-strand tradeoffs.
- Accountability for outcomes; final sign-off on changes to DNA.
- Executing defined sequences within constraints (agents, automations).
- Pattern enforcement: linting, validation, policy checks.
- Drafting: summaries, first-pass proposals, PRs under templates.
- Retrieval and monitoring: surface signals, anomalies, and deltas.
- Logging and traceability: produce artifacts for review.
Default rule: If the cost of a wrong decision is high or irreversible, keep it Human or Hybrid. If it’s repetitive, checkable, and reversible, make it AI.
What Makes a Good Gene?
1. Atomic
It answers ONE specific question. Not a collection of related ideas—one decision. ❌ Bad: “Our design should be clean, consistent, and user-friendly” ✅ Good: “Use max one primary button per screen section”2. Actionable
Someone can apply it immediately without interpretation. ❌ Bad: “We value speed” ✅ Good: “Ship MVPs in 2-week sprints, iterate based on feedback”3. Explicit
No room for interpretation. Two people reading it make the same choice. ❌ Bad: “Use color intentionally” ✅ Good: “Brand colors only for interactive elements—buttons, links, focus states”4. Contextual
It includes WHY, not just WHAT. ❌ Bad: “Use TypeScript” ✅ Good: “Use TypeScript (prevents runtime errors, improves refactoring confidence)“5. Constraining
It eliminates options. That’s the point. ❌ Bad: “Consider user needs when designing” ✅ Good: “Modals for actions, pages for destinations—no exceptions”Gene Anatomy
Every gene has five parts:Gene Examples Across Strands
Brand Gene
Product Gene
UI Gene
UX Gene
Tech Gene
Data Gene
Conversation Gene
Operations Gene
Sales Gene
AI Gene
Security Gene
AI Governance Gene (New)
Gene Density
How many genes should you have? There’s no fixed number. But here are guidelines:Early-stage startup (5-20 people):
- 20-40 genes total
- Focus on Brand, Product, UI, Tech
Growth stage (20-100 people):
- 60-120 genes total
- Add Operations, Sales, Data, UX
Scale stage (100+ people):
- 150-300 genes total
- All 12 strands well-developed
When to Create a Gene
Create a gene when:- A decision gets debated more than once “Should this be a modal or page?” → Time for a gene
- Different people make different choices Inconsistent button styles → Gene needed
- A pattern emerges organically Team naturally converges on a pattern → Encode it
- Onboarding reveals gaps New hire asks “how do we handle X?” → Document as gene
- A mistake happens repeatedly Same error keeps occurring → Constrain it with a gene
Gene Evolution
Genes aren’t permanent. They evolve:Mutation
A gene changes because context changedInheritance
A new gene extends an existing oneDeprecation
A gene becomes obsoleteThe Power of Genes
Genes eliminate micro-decisions. Instead of:- “Let me ask the team”
- “Let me schedule a meeting”
- “Let me check with my manager”
- Check the gene
- Apply the rule
- Move forward
Next: Sequences
Genes are rules. Sequences show how genes work together.Learn About Sequences
Cross-company workflows that apply multiple genes (run by Humans, AI, or Hybrid)

